Wound Repair

The natural way to treat chronic wounds

If you suffer from chronic wounds, you’re aware of how painful and debilitating they can be. Left untreated, they can cause serious damage to your health and hinder your lifestyle dramatically. Repair by Nature’s Chronic Wound Repair Supplement offers a solution to chronic conditions that not only targets the wound but improves your overall health.  

What are chronic wounds?

Under normal conditions, wounds heal naturally in stages over a predictable amount of time. However, when a wound hasn’t healed within three months, it is classified as chronic. 1 Chronic wounds develop for several reasons, which can be grouped into systemic and local factors. 2 The local factors include aspects like wound hygiene, infections, and pressure, and are often linked to postoperative patients. On the other hand, systemic factors are mostly out of our control, such as diabetes and aging, both of which hinder the wound healing process. 

 

Diabetic wounds

Despite these differences, many chronic wounds stall in the inflammation phase of healing and can therefore be treated using similar methods. 3 Diabetes related wounds are one of the most common examples of this, and with over 400 million people suffering from type 2 diabetes alone, it is a major worldwide health issue. 4 The long-term effects of high blood sugar levels (hyperglycemia) can cause diabetic neuropathy, which is nerve damage that mostly affects the legs and feet. 5 This causes ulcers, commonly known as diabetic leg and foot ulcers, which can last over a year and recur in up to 70% of patients. These ulcers can result in loss of function of the limb, and a significant decrease in quality of life 6

To combat this problem, it’s worth getting to the root cause — inflammation. Diabetics suffer from an increase glucose flux, which enhances oxidant production and impairs antioxidant defenses. This is why diabetic wounds are typically associated with a persistent inflammatory response. During normal wound healing, there is a switch from proinflammatory to prohealing macrophages. However, the diabetic and chronic wound environment impairs the switch, and is stuck in a pro-inflammatory response, or a state of oxidative stress 7.  

Treating diabetic chronic wounds

The treatment methods available often focus on treating hyperglycemia with insulin and other pharmacological medicines that are not completely efficient and can lead to unwanted side effects. With chronic wound treatment now a field of its own and the medical costs rising, alternative treatment options are in demand. Repair by Nature is focused on meeting the demand by bringing a natural alternative to the wound care market. 

Diabetic toe amputation wound healing progress using Chronic Wound Repair

Diabetic toe amputation wound healing progress using Chronic Wound Repair

Repair By Nature's treatment

Polyphenols are chemical compounds found in many plants, which have the ability to terminate any chain reactions produced by oxidative stress 8. The Cyclopia plant (Honeybush) is home to polyphenols Mangiferin, as well as Iso Mangiferin and Hesperidin. These compounds are a major source of natural antioxidants, which can combat diabetic wounds in a hyperglycemia-induced oxidative environment 9. In addition to being a potent antioxidant, Mangiferin possesses antihyperglycemic activity and can improve insulin production and the distribution of glucose to stablise blood sugar levels  10

 As a wound healing agent, Mangiferin has several benefits that improve healing time and wound outcome. The high levels of Vitamin E act as an antioxidant in the skin and forms more stable cell membranes, which stops the inflammatory response and promotes collagen synthesis. The Vitamin C in Mangiferin further promotes collagen formation, and Vitamin A contributes to bone formation. Mangiferin, Iso Mangiferin and Hesperidin also prevent wound swelling and itching by inhibiting the release of allergic mediators such as histamine and serotonin 11

Surgical wound healing progress using Chronic Wound Repair

Surgical wound healing progress using Chronic Wound Repair

 The antihyperglycemic and antioxidant effect of the Cyclopia honeybush plant, which forms the key ingredient in Repair by Nature’s Chronic Wound Repair Supplement, allows people who suffer from diabetic induced wounds or wounds of any kind to treat their chronic condition in a safe and natural way. 

 
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1 Zhang, X. (Jan, 2017). ‘NLPR3 inflammasome expression and signaling in human diabetic wounds and in high glucose induced macrophages’. Retrieved from US National Library of Medicine.

2 Builder, P. (Nov, 2015). ‘Wound care: traditional African medicine approach’. Retrieved from InTechOpen.

3 Frykberg, R., Banks, J. (Aug, 2015). ‘Challenges in the treatment of chronic wounds’. Retrieved from Mary Ann Liebert Inc. Publishers.

4 Du, S, et al. (Oct, 2018). ‘Mangiferin: an effective therapeutic agent against several disorders’. Retrieved from Molecular Medicine Reports.

5 Pletcher, P. (Oct, 2016). ‘Diabetes leg pain and cramps: treatment tips’. Retrieved from Healthline.

6 Frykberg, R., Banks, J. (Aug, 2015). ‘Challenges in the treatment of chronic wounds’. Retrieved from Mary Ann Liebert Inc. Publishers.

7 Zhang, X. (Jan, 2017). ‘NLPR3 inflammasome expression and signaling in human diabetic wounds and in high glucose induced macrophages’. Retrieved from US National Library of Medicine.

8 Builder, P. (Nov, 2015). ‘Wound care: traditional African medicine approach’. Retrieved from InTechOpen.

9 Song, Y., et al. (Feb, 2020). ‘Mangiferin Alleviates Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice through Regulating the PTEN/PI3K/Akt Signaling Pathway’. Retrieved from Hindawi Journal of Diabetes Research.

10 Shanmugam, M. (Apr, 2015). ‘Effect of mangiferin on hyperglycemia and atherogenicity in STZ diabetic rats’. Retrieved from Research Gate.

11 Sushanth, K., et al. (2016). ‘Evaluation of wound healing activity with a new formulation of dry mangifera indica and honey using swiss albino mice’. Retrieved from Asian Journal of Pharmaceutical and Clinical Research. 


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