Inflammation

Fight inflammation with Mangiferin Plus

Meet Mangiferin Plus: Nature’s Potent Anti-Inflammatory

The key natural ingredients in Repair by Nature’s Mangiferin Plus product are the polyphenol’s mangiferin and hesperidin. Together, these chemical compounds have potent anti-inflammatory properties that can be used to treat a multitude of inflammation related diseases. 

Mangiferin’s ability to inhibit the production of major inflammation triggers in our body makes it a powerful herbal anti-inflammatory therapeutic. To explain how this micronutrient works to fight inflammation, it’s helpful to understand what inflammation is, and what it does to the body. 

What is inflammation?

Inflammation is our body’s natural response to foreign organisms, such as bacteria and viruses that enter our body when we are sick or injured. Our white blood cells attack the foreign organism, causing the characteristic swelling, redness, and pain we experience after a cut finger or sprained ankle. This type of inflammation is called acute inflammation, and it protects us against harmful foreign invaders by repairing damaged tissue and healing wounds.1


However, there is another side to inflammation that can be harmful rather than helpful to your health. This type of inflammation is called chronic inflammation. It often begins with the same cellular response, but morphs into a lingering state that can persist for months or years when the immune system fails to solve the problem.2


Chronic inflammation can also develop into autoimmune diseases, where an inflammatory response becomes activated even when there is no injury or disease. The immune system mistakes its own tissue as foreign, and prompts white blood cells to attack healthy tissues and organs, setting up a chronic inflammatory process that is largely responsible for some of the most prevalent diseases today, including arthritis, cancer, heart disease, diabetes, asthma, and Alzheimer’s.3


The inflammatory chain reaction 

The common thread in chronic inflammation is an overproduction of pro-inflammatory chemicals in the body. One of these chemicals is known as NLRs (nucleotide binding domain, leucine rich repeat containing receptors),  which forms inflammasomes.4  Inflammasomes are responsible for the chain reaction that perpetuates inflammation. When a particular inflammasome called NLRP3 is activated, it activates caspase 1, which then activates the pro-inflammatory cytokines.The overproduction of cytokines is then what leads to inflammation of body tissue. For example, too many cytokines in the joints can lead to rheumatoid arthritis.6


NLRP3 inflammasome plays a part in a wide variety of diseases, including genetically inherited autoinflammatory conditions as well as chronic diseases such as Alzheimer's disease, atherosclerosis, metabolic syndrome, and age-related macular degeneration.7

How does Mangiferin treat chronic inflammation?

When we experience chronic inflammation, the goal is to get our body to retreat and restore its natural balance by shutting down the excessive inflammatory response.8 Mangiferin does this by inactivating the NLRP3 inflammasome and returning it to its usual inactive state.9 This inhibits the chain reaction, and helps the body to stop the overproduction of pro-inflammatory chemicals. 


With proven efficacy, herbs and dietary supplements offer a safer alternative treatment for pain relief, especially for long-term use. Mangiferin’s ability to block excessive NLP3 activation is an ideal treatment for people who suffer from chronic inflammation and are looking to treat the condition in a natural, health-focused way.10


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1  Web MD. (Nd). ‘What is inflammation?’ Retrieved from WebMD. Date Accessed: 26/12/2019.
2  Harvard Medical School Guide. (Nd). ‘Understanding inflammation’. Retrieved from Harvard Medical School Guide. Date Accessed: 22/12/2019.
3  Harvard Medical School Guide. (Nd). ‘Understanding inflammation’. Retrieved from Harvard Medical School Guide. Date Accessed: 22/12/2019.
4  Bulugonda, R., Kumar, K., Gangappa, D., et al. (Feb, 2017). ‘Mangiferin from Pueraria Tuberosa reduces inflammation via inactivation of NLRP3 inflammasome’. Retrieved from Nature Research Journal.
5  Latz, E., Xiao, T., Stutz., A. (Jun, 2013). ‘Activation and regulation of inflammasomes’. Retrieved from US National Library of Medicine National Institutes of Health.
6  Massachusetts General Hospital. (2011). ‘Inflammation and autoimmune disease’. Retrieved from Glue Grant.
7  Ozaki, E., Campbell, M., Doyle, S. (Jan, 2015). ‘Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives’. Retrieved from Research Gate.
8  Neal, B. (Oct, 2018). ‘What’s the difference between good and bad inflammation? Here’s what to watch out for’. Retrieved from Bustle.
9  Bulugonda, R., Kumar, K., Gangappa, D., et al. (Feb, 2017). ‘Mangiferin from Pueraria Tuberosa reduces inflammation via inactivation of NLRP3 inflammasome’. Retrieved from Nature Research Journal.
10  Maroon, J., Bost, J., Maroon, A. (Dec, 2010). ‘Natural anti-inflammatory agents for pain relief’. Retrieved from Surgical Neurology International.

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