Combat ageing with Collagen

Why do we age, and how does CycloferinTM help?

What is collagen? 

Collagen is the most abundant protein in the human body, making up about 70% of the skin protein.1  Found predominantly in connective tissue such as skin, muscles, and bones, collagen gives our body the strength and structure it needs to keep functioning normally. 

Endogenous collagen is the naturally occurring collagen that our bodies produce daily.2  Exogenous collagen on the other hand, is synthetic and comes in the form of supplements usually made from animal extracts. These supplements are intended to replace the collagen we lose as we age.  However, our bodies often find exogenous collagen difficult to absorb, leaving us with disappointing results. CycloferinTM, with its potent antioxidant properties, is unique because it protects our natural endogenous collagen instead of adding foreign collagen. This keeps our skin looking young and healthy in a natural way. 

How does collagen work?

Collagen is made in the middle layer of our skin called the dermis, and is the most plentiful protein in this layer alongside elastin.3 These two proteins work together in the dermis to give us the firm and plump complexions of our youth. Fibroblasts are the cells in the dermis that grow new collagen, and when this process works perfectly there is an abundance of healthy collagen giving our skin bouncy structure.  However, as we age the production of collagen begins to slow down. 

Oxidants and free radicals  

One of the main reasons behind the slowing down of collagen production is an increase in free radicals. As we age, we lose our ability to fight free radicals, allowing them to increase more rapidly.4 Free radicals are molecules with an electron that is unpaired. In normal conditions, electrons spin in their orbits in pairs, like partners or a happy couple. If the single free radical decides to steal an electron from another molecule to complete it’s pair, we say it’s acting like an oxidant.5  By stealing electrons from other molecules, oxidants change the structure of these molecules, which causes cell damage. 

Where do free radicals come from? 

Free radicals come from our normal bodily processes like breaking down nutrients and metabolism, and from external factors like stress, smoking, and sun exposure.6  Unfortunately we can’t prevent these natural processes, but we can limit environmental damage to a certain extent.  To help defend us from free radicals or the process of oxidation, we need antioxidants.  Antioxidants are molecules capable of prohibiting the oxidation of other molecules.  A balance between free radicals and antioxidants is necessary for our bodies to function properly, and if an imbalance occurs we experience a condition called oxidative stress.7

What happens when we undergo oxidative stress?

In this state, oxidation overwhelms our antioxidant defense system. This results in the activation of many ECM (extracellular matrix) enzymes.8  One of these enzymes is collagenese, which is responsible for breaking down the bonds in collagen.  When oxidation affects proteins like collagen, the protein structure changes so they can no longer function normally, which causes production to slow down.  Over time, these changes in the protein’s organisation caused by oxidation can lead to the signs of aging we see on our skin, like wrinkles. 

The importance of antioxidants

While we can’t prevent our skin from aging, antioxidants help us maintain a defense system that slows down the effects of oxidation.9  Although almost all organisms have an antioxidant protection system, these systems are often insufficient to fully prevent damage.  Synthetic antioxidants have been reported to be dangerous for human health, which has inspired medical researchers to look to nature for effective, nontoxic antioxidants.10

Plants have an abundance of antioxidant properties that inhibit free radicals and protect our bodies from oxidative stress.  Eating antioxidant rich foods is part of this process, and supplements can help increase the rate and volume at which our bodies absorb antioxidants, which becomes increasingly necessary as we age.  How well our bodies can absorb the nutrients in the form of a drug or supplement, known as bioavailability, is fundamental to how effective they are. 

How does CycloferinTM combat aging? 

A key ingredient in CycloferinTM is a polyphenol compound known as mangiferin, which is easily absorbed through the walls of our intestinal tract.11 Taken from the honeybush plant grown in South Africa, this ingredient is a powerful natural antioxidant with photoprotective properties, meaning it controls free radicals generated by sun exposure.12  When we keep the balance between free radical formation and antioxidants, we can prevent oxidative stress.  If the body doesn’t enter this state, the enzyme collagenase isn’t activated and collagen bonds aren’t broken down in this way.  This approach to anti-aging and collagen regeneration focuses on prohibiting the root cause of cellular damage.  CycloferinTM encourages the body to repair itself as opposed to trying to replace collagen after it’s broken down.  This is a unique approach to anti-aging, as the majority of collagen supplements contain synthesized collagen from animals.  The issue with this approach is that our bodies struggle to absorb the replacement collagen, which is why at Repair by Nature we focus on stopping the initial damage.13

CycloferinTM’s photoprotective and antioxidant properties, as well as it’s bioavailability are what make it an effective product in the fight for healthy ageing.14 The safety, dependability and lesser side effects of the plant based formula ensure it is a healthy choice for everybody.  The science and long history behind honeybush as a therapeutic medicine in Africa contributes to its reputation as a trusted phytopharmaceutical that encourages our skin to age gracefully and naturally.  



1  McIntosh, J. (Jun, 2017). ‘What is collagen and why do people need it?’ Retrieved from Medical News Today.
2  Cobb, C. (Jun, 2017). ‘What is collagen and why do people use it?’ Retrieved from Medical News Today.
(Mar, 2016). ‘Skin’. Retrieved from Cleveland Clinic.
4  Villiners, Z., Wilson, D. (Jul, 2017). ‘How do free radicals affect the body?’ Retrieved from Medical News Today.
5  Miller, M. (Aug, 2016). ‘Are oxidants the same as free radicals?’ Retrieved from Linkedin.
6  Lobo, V., Patil, A., Phatak, A., Chandra, N. (Dec, 2010). Free radicals, antioxidants and functional foods: Impact on human health’. Retrieved from Phamacognosy Review.
7  Lobo, V., Patil, A., Phatak, A., Chandra, N. (Dec, 2010). Free radicals, antioxidants and functional foods: Impact on human health’. Retrieved from Phamacognosy Review.
8  Ochocka, R., Hering, A., Stefanowicz–Hajduk, J., Cal, K., Barańska, H., (Jul, 2017). The effect of mangiferin on skin: penetration, permeation and inhibition of ECM enzymes.’ Retrieved from Plos One Research Journal.
9  Ai Pham-Huy, L., Hua, H., Pham-Huy, C. (Jun, 2008). ‘Free radicals, antioxidants in disease and health’. Retrieved from International Journal of Biomedical Science.
10  Lobo, V., Patil, A., Phatak, A., Chandra, N. (Dec, 2010). Free radicals, antioxidants and functional foods: Impact on human health’. Retrieved from Phamacognosy Review.
11  Lehman, S. (Jun, 2019). ‘The benefits of phenolic acids and where to find them in your diet’. Retrieved from Very Well Fit.
12  Ochocka, R., Hering, A., Stefanowicz–Hajduk, J., et al. (Jul, 2017). The effect of mangiferin on skin: penetration, permeation and inhibition of ECM enzymes.’ Retrieved from Plos One Research Journal.
13  Moodie, A. (Nd). ‘Why your skin needs collagen to stay young’. Retrieved from BulletProof.
14  Imran, M., Arshad, M., Butt, M., et al. (May, 2017). ‘Mangiferin: a natural miracle bioactive compound against lifestyle related disorders. Retrieved from US National Library of Medicine.

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